خانم نسرین مقدس شریف(Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes)

Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes

Background and Aim: To compare the effect of cyclopentolate versus tropicamide eye drops on anterior surface corneal parameters using Keratograph 4 in myopic and emmetropic individuals

Methods: Fifty-eight participants included 29 emmetropic and 29 myopic individuals, were recruited, according to inclusion and exclusion criteria. At baseline visit, anterior surface corneal parameters were measured using Keratograph 4 in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions

Results: Of 58 participants who completed the study, 29 (24 women, 5 men, age: 23.82± 2.78 years) were emmetropic and 29 (21women, 8 men, age: 23.66± 2.76 years) were myopic. Baseline mean spherical equivalents were -0.23±0.23 D and -2.45±1.03 D in emmetropic and myopic groups, respectively. The analysis of the data showed a significant hyperopic shift following instillation of both cycloplegic eye drops in both refractive groups. However, tropicamide results was statistically insignificant in comparison with cyclopentolate (p=0.49). The assessment of data revealed no statistically significant differences in anterior surface corneal parameters in baseline, tropicamide and cyclopentolate instillation in each refractive group, except index of height decentration (IHD) value with tropicamide in myopic group (p=0.02). The further analysis between refractive groups also showed no significant differences in anterior surface corneal parameters in each session

Conclusion: Present study indicates that cyclopentolate and tropicamide do not appear to affect corneal topographic parameters and hence can be trusted to capture topography data

Nasrin Moghadas Sharif¹ , Hadi Ostadi Moghadam ² , Elham Azizi ³ , Elahe Ghoochani ³ , Asieh Ehsaei ⁴ *

1. 1. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
2. Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
4. 1. Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran 2. Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran