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آقای دکتر مسعود خرمی نژاد(Pediatric Eye Disease Investigator Group Studies and the Challenges Ahead)

آقای دکتر مسعود خرمی نژاد(Pediatric Eye Disease Investigator Group Studies and the Challenges Ahead)

Pediatric Eye Disease Investigator Group Studies and the Challenges Ahead

Affiliation

Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences.

Abstract

Amblyopia is one of the most common causes of preventable visual loss in children. A large body of research was performed in the treatment of different types of amblyopia. However, the most of previous study before the year 2000 were retrospective and nonrandomized researches.

The Pediatric Eye Disease Investigator Group (PEDIG), which was supported by National Eye Institute (NEI), has performed several well design prospective randomized clinical trials. According to results of these studies, refractive correction alone in different types of refractive amblyopia are a powerful treatment and adding occlusion therapy with spectacles was superior to refractive correction alone. In addition, initiating fewer hours of occlusion therapy was as effective as full time patching. Occlusion therapy was effective in older children, especially if their amblyopia had not previously been treated. Beside, weekend atropine as a pharmacological penalization was as effective as occlusion therapy.

Although the PEDIG studies are the greatest exist evidences in this field, there are some main limitations such as they did not provide any recommendation about amblyopia treatment in infants and uncooperative patients. In this presentation, the author will have discussed about these issues.

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